Publikationen: Prof. Timo Kirschstein


Müller S, Kartheus M, Hendinger E, Hübner DC, Schnell E, Rackow S, Bertsche A, Köhling R, Kirschstein T. (2024) Persistent Kv7.2/7.3 downregulation in the rat pilocarpine model of mesial temporal lobe epilepsy. Epilepsy Res. 200: 107296.

Petereit C, Porath K, Rackow S, Kernig K, Hakenberg OW, Köhling R, Kirschstein T. (2024) Age-dependent effects of the β3 adrenoceptor agonist CL316,243 on human and rat detrusor muscle strips. Pflügers Arch. Eur. J. Physiol. 476(2): 243-256.


Kirschstein T, Köhling R. (2023) Functional changes in neuronal circuits due to antibody-driven autoimmune response. Neurobiol. Dis. 184: 106221.

Frerker B, Fiedler S, Kirschstein T, Lange F, Porath K, Sellmann T, Kutzner L, Wilde F, Moosmann J, Köhling R, Hildebrandt G, Schültke E. (2023) Effects Of Microbeam Irradiation On Rodent Esophageal Smooth Muscle Contraction. Cells 12: 176.

Lange F, Porath K, Sellmann T, Einsle A, Jaster R, Linnebacher M, Köhling R, Kirschstein T. (2023) Direct current electrical field stimulation of patient-derived colorectal cancer cells. Biology 12(7): 1032.

Küpper M, Porath K, Sellmann T, Bien CG, Köhling R, Kirschstein T. (2023) GluN2B inhibition rescues impaired potentiation and epileptogenicity at associational-commissural CA3 synapses in a model of anti-NMDAR encephalitis. Neurosci. Lett. 795: 137031.


Lange F, Kirschstein T, Davis J, Paino J, Barnes M, Klein M, Porath K, Stöhlmacher P, Fiedler S, Frank M, Köhling R, Hildebrandt G, Hausermann D, Lerch M, Schültke E. (2022) Microbeam irradiation of the beating rodent heart: an ex vivo study of acute and subacute effects on cardiac function. Int. J. Radiat. Oncol. Biol. Phys. 114(1): 143-152.

Schültke E, Lerch M, Kirschstein T, Lange F, Porath K, Fiedler S, Davis J, Paino J, Engels E, Barnes M, Klein M, Hall C, Häusermann D, Hildebrandt G. (2022) Modification of the Langendorff system of the isolated beating heart for experimental radiotherapy at the synchrotron: 4,000 Gy in a heart beat. J. Synchrotron Radiat. 29: 1027-1032.

Hörnschemeyer J, Kirschstein T, Reichart G, Sasse C, Venus J, Einsle A, Porath K, Linnebacher M, Köhling R, Lange F. (2022) Studies on biological and molecular effects of small-molecule kinase inhibitors on human glioblastoma cells and organotypic brain slices. Life 12(8): 1258.

Lange F, Venus J, Shams Esfand Abady D, Porath K, Einsle A, Sellmann T, Neubert N, Reichart G, Linnebacher M, Köhling R, Kirschstein T. (2022) Galvanotactic migration of glioblastoma and brain metastases cells. Life 12: 580.


Laker D, Tolle F, Stegen M, Heerdegen M, Köhling R, Kirschstein T, Wolfart J. (2021) Kv7 and Kir6 channels shape the slow AHP in mouse dentate gyrus granule cells and control burst-like firing behavior. Neuroscience 467: 56-72.

Lange F, Hörnschemeyer J, Kirschstein T. (2021) Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy. Cells 10(5): 1226.
Müller L, Kirschstein T, Köhling R, Kuhla A, Teipel S. (2021) Neuronal hyperexcitability in APPswe/PS1dE9 mouse models of Alzheimer’s disease. J. Alzheimers Dis. 81(3): 855-869.

Madadi A, Wolfart J, Lange F, Brehme H, Linnebacher M, Bräuer AU, Büttner A, Freiman T, Henker C, Einsle A, Rackow S, Köhling R, Kirschstein T, Müller S. (2021) Correlation between Kir4.1 expression and barium-sensitive currents in rat and human glioma cell lines. Neurosci. Lett. 741: 135481.


Lange F, Hartung J, Liebelt C, Boisserée J, Resch T, Porath K, Hörnschemeyer J, Reichart G, Sellmann T, Neubert V, Kriesen S, Hildebrandt G, Schültke E, Köhling R, Kirschstein T. (2020) Perampanel add-on to standard radiochemotherapy in vivo promotes neuroprotection in a rodent F98 glioma model. Front. Neurosci. 14: 598266.

Kirschstein T, Sadkiewicz E, Hund-Göschel G, Becker J, Guli X, Müller S, Rohde M, Hübner DC, Brehme H, Kolbaske S, Porath K, Sellmann T, Großmann A, Wittstock M, Syrbe S, Storch A, Köhling R. (2020) Stereotactically injected Kv1.2 and CASPR2 antisera cause differential effects on CA1 synaptic and cellular excitability, but both enhance the vulnerability to pro-epileptic conditions. Front. Synaptic Neurosci. 12: 13.

Frerker B, Rohde M, Müller S, Bien CG, Köhling R, Kirschstein T. (2020) Distinct effects of stereotactically injected human cerebrospinal fluid containing glutamic acid decarboxylase antibodies into the hippocampus of rats on the development of spontaneous epileptic activity. Brain Sci. 10: 123.

Schulze F, Müller S, Guli X, Schumann L, Brehme H, Riffert T, Rohde M, Goerss D, Rackow S, Einsle A, Kirschstein T, Köhling R. (2020) CK2 inhibition prior to status epilepticus persistently enhances KCa2 function in CA1 which slows down disease progression. Front. Cell. Neurosci. 14: 33.

Mayer J, Kirschstein T, Resch T, Porath K, Krause BJ, Köhling R, Lange F. (2020) Perampanel attenuates epileptiform phenotype in C6 glioma. Neurosci. Lett. 715: 134629.


Rohde M, Ziebart J, Kirschstein T, Sellmann T, Porath K, Kühl F, Delenda B, Bahls C, Van Rienen U, Bader R, Köhling R. (2019) Human osteoblast migration in DC electrical fields depends on store operated Ca2+ release and is correlated to upregulation of stretch-activated TRPM7 channels. Front. Bioeng. Biotechnol. 7: 422.

Zschorlich V, Hillebrecht M, Tanjour T, Qi F, Behrendt F, Kirschstein T, Köhling R. (2019) Repetitive peripheral magnetic nerve stimulation (rPMS) as adjuvant therapy reduces skeletal muscle reflex activity. Front. Neurol. 10: 930.

Kersten M, Rabbe T, Blome R, Porath K, Sellmann T, Bien CG, Köhling R, Kirschstein T. (2019) Novel object recognition in rats with NMDAR dysfunction in CA1 after stereotactic injection of anti-NMDAR encephalitis cerebrospinal fluid. Front. Neurol. 10: 586.

Lange F, Weßlau K, Porath K, Hörnschemeyer J, Bergner C, Krause BJ, Mullins CS, Linnebacher M, Köhling R, Kirschstein T. (2019) AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro. PloS One 14(2): e0211644.


Reichart G, Mayer J, Johne C, Kirschstein T, Tokay T, Lange L, Baltrusch S, Tiedge M, Fuellen G, Ibrahim S, Köhling R. (2018) Mitochondrial complex IV mutation increases ROS production and reduces lifespan in aged mice. Acta Physiol. e13214.

Walter U, Fernández-Torre JL, Kirschstein T, Laureys S. (2018) When is “brainstem death” brain death? The case for ancillary testing in primary infratentorial brain lesion. Clin. Neurophysiol. 129: 2451-2465.

Bajorat R, Porath K, Kuhn J, Goßla E, Goerss D, Sellmann T, Köhling R, Kirschstein T. (2018) Oral administration of the casein kinase 2 inhibitor TBB leads to persistent KCa2.2 channel up-regulation in the epileptic CA1 area, but lacks antiseizure efficacy in the pilocarpine epilepsy model. Epilepsy Res. 147: 42-50.

Blome R, Bach W, Guli X, Porath K, Sellmann T, Bien C, Köhling R, Kirschstein T. (2018) Differentially altered NMDAR dependent and independent long-term potentiation in the CA3 subfield in a model of anti-NMDAR encephalitis. Front Synaptic Neurosci. 10: 26.

Mader F, Müller S, Krause L, Springer A, Kernig K, Protzel C, Porath K, Rackow S, Wittstock T, Frank M, Hakenberg OW, Köhling R, Kirschstein T. (2018) Hyperpolarization-Activated Cyclic Nucleotide-Gated Non-selective (HCN) Ion Channels Regulate Human and Murine Urinary Bladder Contractility. Front Physiol. 9: 753.

Müller S, Guli X, Hey J, Einsle A, Pfanz D, Sudmann V, Kirschstein T, Köhling R. (2018) Acute epileptiform activity induced by gabazine involves proteasomal rather than lysosomal degradation of KCa2.2 channels. Neurobiol. Dis. 112: 79-84.

Dammann F, Kirschstein T, Guli X, Müller S, Porath K, Rohde M, Tokay T, Köhling R. (2018) Bidirectional shift of group III metabotropic glutamate receptor-mediated synaptic depression in the epileptic hippocampus. Epilepsy Res. 139: 157-63.

Li S, Kumar P, Joshee S, Kirschstein T, Subburaju S, Khalili JS, Kloepper J, Du C, Elkhal A, Szabó G, Jain RK, Köhling R, Vasudevan A. (2018) Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior. Cell Res. 28: 221-48.


Neumann AM, Abele J, Kirschstein T, Engelmann R, Sellmann T, Köhling R, Müller-Hilke B. (2017) Mycophenolate mofetil prevents the delayed T cell response after pilocarpine-induced status epilepticus in mice. PLoS ONE 12(11): e0187330.

Rehberg M, Kirschstein T, Guli X, Müller S, Rohde M, Franz D, Tokay T, Köhling R. (2017) Functional metaplasticity of hippocampal Schaffer collateral-CA1 synapses is reversed in chronically epileptic rats. Neural Plast. 2017: 8087401.

Hahn H, Kropp P, Kirschstein T, Rücker G, Müller-Hilke B. (2017) Acute test anxiety in medical school does not predict academic performance, but correlates with a perceived imbalance between high efforts spent and low rewards received. PLoS ONE 12(2): e0171220.

Schindler N, Mayer J, Saenger S, Gimsa U, Walz C, Brenmoehl J, Ohde D, Wirthgen E, Tuchscherer A, Russo VC, Frank M, Kirschstein T, Metzger F, Hoeflich A. (2017) Phenotype analysis of male transgenic mice overexpressing mutant IGFBP-2 lacking the Cardin-Weintraub sequence motif: Reduced expression of synaptic markers and myelin basic protein in the brain and a lower degree of anxiety-like behaviour. Growth Horm. IGF Res. 33: 1-8.



Hackert JK, Müller L, Rohde M, Bien CG, Köhling R, Kirschstein T. (2016) Anti-GAD65 containing cerebrospinal fluid does not alter GABAergic transmission. Front Cell Neurosci. 10: 130.

Kirschstein T, Wolters A, Lenz J-H, Fröhlich S, Hakenberg O, Kundt G, Darmüntzel M, Hecker M, Altiner A, Müller-Hilke B. (2016) An algorithm for calculating exam quality as a basis for performance-based allocation of funds at medical schools. GMS J Med Educ. 33(3): Doc44.

Fröscher W, Kirschstein T, Rösche J. (2016) Anticonvulsant therapy in brain-tumor related epilepsy. J Epileptol. 24: 35-50.

Avchalumov Y, Kirschstein T, Köhling R. (2016) Loss of GABAergic control of corticostriatal LTP following status epilepticus. Transl Brain Rhythm. 1: 3-6.

Mader F, Krause L, Tokay T, Hakenberg OW, Köhling R, Kirschstein T. (2016) P2Y receptor-mediated transient relaxation of rat longitudinal ileum preparations involves phospholipase C activation, intracellular Ca2+ release and SK channel activation. Acta Pharmacol Sin.37: 617-28.

Bajorat R, Goerss D, Brenndörfer L, Schwabe L, Köhling R, Kirschstein T. (2016) Interplay between interictal spikes and behavioral seizures in young, but not aged pilocarpine-treated epileptic rats. Epilepsy Behav. 57(Pt A):90-94.

Guli X, Tokay T, Kirschstein T, Köhling R. (2016) Status Epilepticus Enhances Depotentiation after Fully Established LTP in an NMDAR-Dependent but GluN2B-Independent Manner. Neural Plast. 2016:6592038.

Würdemann T, Kersten M, Tokay T, Guli X, Kober M, Rohde M, Porath K, Sellmann T, Bien CG, Köhling R, Kirschstein T. (2016) Stereotactic injection of cerebrospinal fluid from anti-NMDA receptor encephalitis into rat dentate gyrus impairs NMDA receptor function. Brain Res. 1633:10-8.

Kirschstein T, Köhling R. (2016) Animal models of tumour-associated epilepsy. J Neurosci Methods.260:109-17.



Kirschstein T, Sahre T, Kernig K, Protzel C, Porath K, Köhling R, Hakenberg OW. (2015) Inverse relationship of Rho kinase and myosin-light chain kinase expression in the aging human detrusor smooth muscle. BMC Urol. 15:104.

Rösche J, Piek J, Hildebrandt G, Grossmann A, Kirschstein T, Benecke R. (2015) [Perampanel in the treatment of a patient with glioblastoma multiforme without IDH1 mutation and without MGMT promotor methylation]. Fortschr Neurol Psychiatr. 83(5):286-9.

Weller J, Pose M, Protzel C, Mader F, Porath K, Köhling R, Hakenberg OW, Kirschstein T (2015). Age-related decrease of adenosine-mediated relaxation in rat detrusor is a result of A2B receptor downregulation. Int J Urol. 22(3):322-9.



Fröscher W, Kirschstein T, Rösche J. (2014) [Anticonvulsant therapy for brain tumour-related epilepsy]. Fortschr Neurol Psychiatr. 82(12):678-90. 

Tokay T, Kirschstein T, Rohde M, Zschorlich V, Köhling R. (2014) NMDA receptor-dependent metaplasticity by high-frequency magnetic stimulation. Neural Plast. 2014:684238.

Avchalumov Y, Sander SE, Richter F, Porath K, Hamann M, Bode C, Kirschstein T, Köhling R, Richter A. (2014) Role of striatal NMDA receptor subunits in a model of paroxysmal dystonia. Exp Neurol. 261:677-84.

Brehme H, Kirschstein T, Schulz R, Köhling R. (2014) In vivo treatment with the casein kinase 2 inhibitor 4,5,6,7- tetrabromotriazole augments the slow afterhyperpolarizing potential and prevents acute epileptiform activity. Epilepsia. 55(1):175-83.

Müller L, Müller S, Sellmann T, Groeneweg L, Tokay T, Köhling R, Kirschstein T. (2014) Effects of oxygen insufflation during pilocarpine-induced status epilepticus on mortality, tissue damage and seizures. Epilepsy Res. 108(1):90-7.

Kirschstein T, Protzel C, Porath K, Sellmann T, Köhling R, Hakenberg OW. (2014) Age-dependent contribution of Rho kinase in carbachol-induced contraction of human detrusor smooth muscle in vitro. Acta Pharmacol Sin. 35(1):74-81.



Klatte K, Kirschstein T, Otte D, Pothmann L, Müller L, Tokay T, Kober M, Uebachs M, Zimmer A, Beck H. (2013) Impaired D-serine-mediated cotransmission mediates cognitive dysfunction in epilepsy. J Neurosci. 33(32):13066-80.

Avchalumov Y, Volkmann CE, Rückborn K, Hamann M, Kirschstein T, Richter A, Köhling R. (2013) Persistent changes of corticostriatal plasticity in dt(sz) mutant hamsters after age-dependent remission of dystonia. Neuroscience. 250:60-9.

Mikkat S, Kirschstein T, Kreutzer M, Glocker MO. (2013) Mass spectrometric peptide analysis of 2DE-separated mouse spinal cord and rat hippocampus proteins suggests an NGxG motif of importance for in vivo deamidation. Electrophoresis. 34(11):1610-8.

Müller L, Tokay T, Porath K, Köhling R, Kirschstein T. (2013) Enhanced NMDA receptor-dependent LTP in the epileptic CA1 area via upregulation of NR2B. Neurobiol Dis. 54:183-93.



Kirschstein T. (2012) Synaptic plasticity and learning in animal models of tuberous sclerosis complex. Neural Plast. 2012:279834.

Guli X, Tokay T, Rohde M, Bender RA, Köhling R, Kirschstein T. (2012) ZD7288 enhances long-term depression at early postnatal medial perforant path-granule cell synapses. Neural Plast. 2012:237913.

Avchalumov Y, Kirschstein T, Lukas J, Luo J, Wree A, Rolfs A, Köhling R. (2012) Increased excitability and compromised long-term potentiation in the neocortex of NPC1(-/-) mice. Brain Res. 1444:20-6.

Rohde J, Kirschstein T, Wilkars W, Müller L, Tokay T, Porath K, Bender RA, Köhling R. (2012) Upregulation of presynaptic mGluR2, but not mGluR3 in the epileptic medial perforant path. Neuropharmacology. 62(4):1867-73.

Schulz R, Kirschstein T, Brehme H, Porath K, Mikkat U, Köhling R. (2012) Network excitability in a model of chronic temporal lobe epilepsy critically depends on SK channel-mediated AHP currents. Neurobiol Dis. 45(1):337-47.

Kernig K, Kirschstein T, Würdemann T, Rohde M, Köhling R. (2012) The afterhyperpolarizing potential following a train of action potentials is suppressed in an acute epilepsy model in the rat Cornu Ammonis 1 area. Neuroscience. 201:288-96.

Kirschstein T, Mikkat S, Mikkat U, Bender R, Kreutzer M, Schulz R, Köhling R, Glocker MO. (2012) The 27-kDa heat shock protein (HSP27) is a reliable hippocampal marker of full development of pilocarpine-induced status epilepticus. Epilepsy Res. 98(1):35-43.



Barmashenko G, Hefft S, Aertsen A, Kirschstein T, Köhling R. (2011) Positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis is widespread after status epilepticus. Epilepsia. 52(9):1570-8.

Bajorat R, Wilde M, Sellmann T, Kirschstein T, Köhling R. (2011) Seizure frequency in pilocarpine-treated rats is independent of circadian rhythm. Epilepsia. 52(9):e118-22.

Avchalumov Y, Kirschstein T, Köhling R. (2011) Altered physiology and pharmacology in the corticostriatal system in a model of temporal lobe epilepsy. Epilepsia. 52(1):151-7.



Tokay T, Rohde M, Krabbe S, Rehberg M, Bender RA, Köhling R, Kirschstein T. (2009) HCN1 channels constrain DHPG-induced LTD at hippocampal Schaffer collateral-CA1 synapses. Learn Mem. 16(12):769-76.

Rohde M, Tokay T, Köhling R, Kirschstein T. (2009) GABA(A) receptor inhibition does not affect mGluR-dependent LTD at hippocampal Schaffer collateral-CA1 synapses. Neurosci Lett. 467(1):20-5.

Kirschstein T, Dammann F, Klostermann J, Rehberg M, Tokay T, Schubert R, Köhling R. (2009) Dopamine induces contraction in the proximal, but relaxation in the distal rat isolated small intestine. Neurosci Lett. 465(1):21-6.

Kirschstein T, Köhling R. (2009) What is the source of the EEG? Clin EEG Neurosci. 40(3):146-9.

Kirschstein T, Rehberg M, Bajorat R, Tokay T, Porath K, Köhling R. (2009) High K+-induced contraction requires depolarization-induced Ca2+ release from internal stores in rat gut smooth muscle. Acta Pharmacol Sin. 30(8):1123-31.

Tokay T, Holl N, Kirschstein T, Zschorlich V, Köhling R. (2009) High-frequency magnetic stimulation induces long-term potentiation in rat hippocampal slices. Neurosci Lett. 461(2):150-4.


1997 – 2007

Kirschstein T, Bauer M, Müller L, Rüschenschmidt C, Reitze M, Becker AJ, Schoch S, Beck H. (2007) Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus. J Neurosci. 27(29):7696-704.

Bender RA, Kirschstein T, Kretz O, Brewster AL, Richichi C, Rüschenschmidt C, Shigemoto R, Beck H, Frotscher M, Baram TZ. (2007) Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. J Neurosci. 27(17):4697-706.

Von der Brelie C, Waltereit R, Zhang L, Beck H, Kirschstein T. (2006) Impaired synaptic plasticity in a rat model of tuberous sclerosis. Eur J Neurosci. 23(3):686-92.

Zhang L, Kirschstein T, Sommersberg B, Merkens M, Manahan-Vaughan D, Elgersma Y, Beck H. (2005) Hippocampal synaptic metaplasticity requires inhibitory autophosphorylation of Ca2+/calmodulin-dependent kinase II. J Neurosci. 25(33):7697-707.

Kirschstein T, von der Brelie C, Steinhäuser M, Vinçon A, Beck H, Dietrich D. (2004) L-CCG-I activates group III metabotropic glutamate receptors in the hippocampal CA3 region. Neuropharmacology. 47(2):157-62.

Dietrich D, Kirschstein T, Kukley M, Pereverzev A, von der Brelie C, Schneider T, Beck H. (2003) Functional specialization of presynaptic Cav2.3 Ca2+ channels. Neuron. 39(3):483-96.

Kirschstein T, Fernández G, Grunwald T, Pezer N, Urbach H, Blümcke I, Van Roost D, Lehnertz K, Elger CE. (2003) Heterotopias, cortical dysplasias and glioneural tumors participate in cognitive processing in patients with temporal lobe epilepsy. Neurosci Lett. 338(3):237-41.

Agnelli G, Becattini C, Kirschstein T. (2002) Thrombolysis vs heparin in the treatment of pulmonary embolism: a clinical outcome-based meta-analysis. Arch Intern Med. 162(22):2537-41.

Sclabas G, Kirschstein T, Uhl W, Hürlimann R, Ruchti C, Büchler MW. (2002) Juvenile idiopathic fibrosing pancreatitis. Dig Dis Sci. 47(6):1230-5.

Uhl W, Roggo A, Kirschstein T, Anghelacopoulos SE, Gloor B, Müller CA, Malfertheiner P, Büchler MW. (2002) Influence of contrast-enhanced computed tomography on course and outcome in patients with acute pancreatitis. Pancreas. 24(2):191-7.

Greffrath W, Kirschstein T, Nawrath H, Treede RD. (2002) Acetylsalicylic acid reduces heat responses in rat nociceptive primary sensory neurons--evidence for a new mechanism of action. Neurosci Lett. 320(1-2):61-4.

Greffrath W, Kirschstein T, Nawrath H, Treede R. (2001) Changes in cytosolic calcium in response to noxious heat and their relationship to vanilloid receptors in rat dorsal root ganglion neurons. Neuroscience. 104(2):539-50.

Kirschstein T, Aeberli D, Zimmermann A, Uhl W, Büchler MW. (2000) Metastatic angiosarcoma of the liver preoperatively presenting as giant hemangioma. Digestion. 62(4):280-3.

Kirschstein T, Greffrath W, Büsselberg D, Treede RD. (1999) Inhibition of rapid heat responses in nociceptive primary sensory neurons of rats by vanilloid receptor antagonists. J Neurophysiol. 82(6):2853-60.

Kirschstein T, Büsselberg D, Treede RD. (1997) Coexpression of heat-evoked and capsaicin-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons. Neurosci Lett. 231(1):33-6.