Publikationen in Peer-Review-Journalen


Lange F, Gade R, Einsle A, Porath K, Reichart G, Maletzki C, Schneider B, Henker C, Dubinski D, Linnebacher M, Köhling R, Freiman TM, Kirschstein T.
A glutamatergic biomarker panel enables differentiating Grade 4 gliomas/astrocytomas from brain metastases.
Front. Oncol. 14:1335401. doi: 10.3389/fonc.2024.1335401

Müller S, Kartheus M, Hendinger E, Hübner DC, Schnell E, Rackow S, Bertsche A, Köhling R, Kirschstein T.
Persistent Kv7.2/7.3 downregulation in the rat pilocarpine model of mesial temporal lobe epilepsy.
Epilepsy Res. 2024 Jan 10:200:107296. PMID: 38219422


Lüttig A, Perl S, Zetsche M, Richter F, Franz D, Heerdegen M, Köhling R, Richter A.
Short-term stimulations of the entopeduncular nucleus induce cerebellar changes of c-Fos expression in an animal model of paroxysmal dystonia.
Brain Res. 2023 Nov 11:148672. PMID: 37956748

Lange F, Porath K, Sellmann T, Einsle A, Jaster R, Linnebacher M, Köhling R, Kirschstein T.
Direct-Current Electrical Field Stimulation of Patient-Derived Colorectal Cancer Cells.
Biology. 2023 Jul 22;12(7):1032. PMID: 37508461

Franz D, Richter A, Köhling R.
Electrophysiological insights into deep brain stimulation of the network disorder dystonia.
Pflugers Arch. 2023 Aug 2. PMID: 37530804

Kirschstein T, Köhling R.
Functional changes in neuronal circuits due to antibody-driven autoimmune response.
Neurobiol Dis. 2023 Jul 4;184:106221. PMID: 37414365

Frerker B, Fiedler S, Kirschstein T, Lange F, Porath K, Sellmann T, Kutzner L, Wilde F, Moosmann J, Köhling R, Hildebrandt G, Schültke E.
Effects of Microbeam Irradiation on Rodent Esophageal Smooth Muscle Contraction.
Cells 2023, 12, 176. PMID: 36611969

Engel N, Dau M, Engel V, Franz D, Klemmstein F, Thanisch C, Kolb J, Frank M, Springer A, Köhling R, Bader R, Frerich B, Wiesmann N, Heimes D,  Kämmerer PW.
Combining Electrostimulation with Impedance Sensing to Promote and Track Osteogenesis within a Titanium Implant.
Biomedicines. 2023 Feb 24;11(3):697. PMID: 36979676


Patejdl R, Zettl UK.
The pathophysiology of motor fatigue and fatigability in multiple sclerosis.
Front Neurol. 2022 Jul 27;13:891415. PMID: 35968278

Barker-Haliski M, Pitsch J, Galanopoulou AS, Köhling R.
A companion to the preclinical common data elements for phenotyping seizures and epilepsy in rodent models. A report of the TASK3-WG1C: Phenotyping working group of the ILAE/AES joint translational task force.
Epilepsia Open. 2022 Dec 2. PMID: 36461665

Revskij D, Runst J, Umstätter C, Ehlers L, Rohde S, Zechner D, Bastian M, Müller-Hilke B, Fuellen G, Henze L, Murua Escobar H, Junghanss C, Kowald A, Walter U, Köhling R, Wolkenhauer O, Jaster R.
Uncoupling protein 2 deficiency of non-cancerous tissues inhibits the progression of pancreatic cancer in mice.
Hepatobiliary Pancreat Dis Int. 2022 Dec 14:S1499-3872(22)00281-8. PMID: 36549966

Küpper M, Porath K, Sellmann T, Bien CG, Köhling R, Kirschstein T.
GluN2B inhibition rescues impaired potentiation and epileptogenicity at associational-commissural CA3 synapses in a model of anti-NMDAR encephalitis.
Neurosci Lett. 2022 Dec 24:137031. PMID: 36574811

Perl S, Lüttig A, Köhling R, Richter A.
Deep brain stimulation in animal models of dystonia.
Neurobiol Dis. 2022 Oct 25;105912. PMID: 36307031

Konstantinos Spiliotis, Konstantin Butenko, Ursula van Rienen, Jens Starke, Rüdiger Köhling 
Complex network measures reveal optimal targets for deep brain stimulation and identify clusters of collective brain dynamics.
Front. Phys. 2022; 10:951724.

Jonathan Edward Dawson, Tina Sellmann, Katrin Porath, Rainer Bader, Ursula van Rienen, Revathi Appali, Rüdiger Köhling
Cell-cell interactions and fluctuations in the direction of motility promote directed migration of osteoblasts in direct current electrotaxis.
Front Bioeng Biotechnol. 2022 Oct 6;10:995326. PMID:36277406

Hörnschemeyer J, Kirschstein T, Reichart G, Sasse C, Venus J, Einsle A, Porath K, Linnebacher M, Köhling R, Lange F.
Studies on Biological and Molecular Effects of Small-Molecule Kinase Inhibitors on Human Glioblastoma Cells and Organotypic Brain Slices.
Life (Basel). 2022 Aug 17;12(8):1258. PMID: 36013437

Klawitter F, Walter U, Patejdl R, Endler J, Reuter DA, Ehler J.
Sonographic Evaluation of Muscle Echogenicity for the Detection of Intensive Care Unit-Acquired Weakness: A Pilot Single-Center Prospective Cohort Study.
Diagnostics (Basel). 2022 Jun 2;12(6):1378. PMID: 35741188

Siebenbrodt K, Schütz V, Costard LS, Neubert N, Alvarez-Fischer D, Seidel K, Schmeck B, Meuth SG, Rosenow F, Bauer S.
Hippocampal Cytokine Release in Experimental Epileptogenesis—A Longitudinal In Vivo Microdialysis Study.
Brain Sci. 2022, 12, 677. PMID: 35625063

Lange F, Kirschstein T, Davis J, Paino J, Barnes M, Klein M, Porath K, Stöhlmacher P, Fiedler S, Frank M, Köhling R, Hildebrandt G, Hausermann D, Lerch M, Schültke E.
Microbeam irradiation of the beating rodent heart: an ex vivo study of acute and subacute effects on cardiac function.
Int J Radiat Oncol Biol Phys. 2022 May 6;S0360-3016(22)00399-6. PMID: 35533907

Schültke E, Lerch M, Kirschstein T, Lange F, Porath K, Fiedler S, Davis J, Paino J, Engels E, Barnes M, Klein M, Hall C, Häusermann D, Hildebrandt G.
Modification of the Langendorff system of the isolated beating heart for experimental radiotherapy at a synchrotron: 4000 Gy in a heart beat.
J. Synchrotron Rad. 2022 Jul 1;29(Pt 4):1027-1032. PMID: 35787570

Wittstock M, Kästner M, Kolbaske S, Sellmann T, Porath K, Patejdl R.
Serial Measurements of Refractive Index, Glucose and Protein to Assess Gastric Liquid Nutrient Transport-A Proof-of-Principal Study.
Front Nutr. 2022 Feb 3;8:742656. PMID: 35187015

Wagdi A, Malan D, Sathyanarayanan U, Beauchamp JS, Vogt M, Zipf D, Beiert T, Mansuroglu B, Dusend V, Meininghaus M, Schneider L, Kalthof B, Wiegert JS, König GM, Kostenis E, Patejdl R, Sasse P, Bruegmann T.
Selective optogenetic control of G q signaling using human Neuropsin.
Nat Commun. 2022;13(1):1765. PMID: 35365606

Lange F, Venus J, Shams Esfand Abady D, Porath K, Einsle A, Sellmann T, Neubert V, Reichart G, Linnebacher M, Köhling R, Kirschstein T.
Galvanotactic Migration of Glioblastoma and Brain Metastases Cells.
Life. 2022; 12(4):580. PMID: 35455071


Vogt M, Schulz B, Wagdi A, Lebert J, van Belle GJ, Christoph J, Bruegmann T, Patejdl R.
Direct optogenetic stimulation of smooth muscle cells to control gastric contractility.
Theranostics. 2021 Mar 20;11(11):5569-5584. PMID: 33859764

Neuhaus O, Köhler W, Bergh FT, Kristoferitsch W, Faiss J, Rosenkranz T, Reske D, Patejdl R, Hartung HP, Zettl UK.
Glatiramer Acetate Treatment in Multiple Sclerosis-Associated Fatigue-Beneficial Effects on Self-Assessment Scales But Not on Molecular Markers.
Biomolecules. 2021 Mar 7;11(3):393. PMID: 33800033

Spiliotis K, Starke J, Franz D, Richter A, Köhling R.
Deep brain stimulation for movement disorder treatment: exploring frequency-dependent efficacy in a computational network model.
Biol Cybern. 2021 Dec 11. PMID:34894291

Plocksties F, Kober M, Niemann C, Heller J, Fauser M, Nüssel M, Uster F, Franz D, Zwar M, Lüttig A, Kröger J, Harloff J, Schulz A, Richter A, Köhling R, Timmermann D, Storch A.
The software defined implantable modular platform (STELLA) for preclinical deep brain stimulation research in rodents.
J Neural Eng. 2021 Sep 21;18(5). PMID: 34542029

Laker D, Tolle F, Stegen M, Heerdegen M, Köhling R, Kirschstein T, Wolfart J.
Kv7 and Kir6 channels shape the slow AHP in mouse dentate gyrus granule cells and control burst-like firing behavior.
Neuroscience (in press) PMID: 34048798

Lange F, Hörnschemeyer J, Kirschstein T.
Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy.
Cells 2021, 10(5), 1226. PMID: 34067762

Müller L, Kirschstein T, Köhling R, Kuhla A, Teipel S.
Neuronal Hyperexcitability in APPSWE/PS1dE9 Mouse Models of Alzheimer's Disease.
J. Alzheimers Dis. 2021;81(3):855-869. PMID: 33843674

Heerdegen M, Zwar M, Franz D, Hörnschemeyer J, Neubert V, Plocksties F, Niemann C, Timmermann D, Bahls C, van Rienen U, Paap M, Perl S, Lüttig A, Richter A, Köhling R.
Mechanisms of pallidal deep brain stimulation: alteration of cortico-striatal synaptic communication in a dystonia animal model.
Neurobiol Dis. 2021 Mar 19:105341. PMID: 33753292

Butenko K, Köhling R, Van Rienen U.
Numerical study on electrode design for rodent deep brain stimulation with implantations cranial to targeted nuclei.
Front. Comput. Neurosci., 02 February 2021. PMID: 33603655


Henze, L, Walter, U, Murua Escobar, H, Junghanß, C, Jaster, R, Köhling, R, Lange, F, Salehzadeh-Yazdi, A, Wolkenhauer, O, Hamed, M, Barrantes, I, Palmer, D, Möller, S, Kowald, A, Heussen, N, Fuellen, G.
Towards biomarkers for outcomes after pancreatic ductal adenocarcinoma and ischemic stroke, with focus on (co-)morbidity and aging / cellular senescence (SASKit): protocol for a prospective cohort study.
BMJ Open 10(12):e039560. PMID: 33334830

Lange F, Hartung J, Liebelt C, Boisserée J, Resch T, Porath K, Hörnschemeyer J, Reichart G, Sellmann T, Neubert V, Kriesen S, Hildebrandt G, Schültke E, Köhling R, Kirschstein T.
Perampanel add-on to standard radiochemotherapy in vivo promotes neuroprotection in a rodent F98 glioma model.
Front. Neurosci., 30 November 2020. PMID: 33328869

Klawitter F, Ehler J, Reuter DA, Patejdl R.
Relations Between Early Neuromuscular Alterations, Gastrointestinal Dysfunction, and Clinical Nutrition in Critically Ill Patients: An Exploratory Single-center Cohort Study.
Neurocrit Care. 2020 Apr 3. PMID: 32246438

Madadi A, Wolfart J, Lange F, Brehme H, Linnebacher M, Bräuer AU, Büttner A, Freiman T, Henker C, Einsle A, Rackow S, Köhling R, Kirschstein T, Müller S.
Correlation between Kir4.1 expression and barium-sensitive currents in rat and human glioma cell lines.
Neurosci Lett. 2020 Nov 5;135481. PMID: 33161102

Paap M, Perl S, Lüttig A, Plocksties F, Niemann C, Timmermann D, Bahls C, van Rienen U, Franz D, Zwar M, Rohde M, Köhling R, Richter A.
Deep brain stimulation by optimized stimulators in a phenotypic model of dystonia: Effects of different frequencies.
Neurobiol Dis. 2020 Nov 6;105163. PMID: 33166698

Brennan GP , Bauer  S, Engel T, Jimenez-Mateos  EM , Del Gallo F, Hill TDM, Connolly NMC, Costard LS, Neubert V, Salvetti B, Sanz-Rodriguez A, Heiland M, Mamad O, Brindley E, Norwood B, Batool A, Raoof  R, El-Naggar H, Reschke CR, Delanty N, Prehn JHM, Fabene P, Mooney C, Rosenow F, Henshall DC
Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy.
Neurobiol Dis. 2020 Aug 13;144:105048. PMID: 32800995

Henke C, Töllner K, van Dijk RM, Miljanovic N, Cordes T, Twele F, Bröer S, Ziesak V, Rohde M, Hauck SM, Vogel C, Welzel L, Schumann T, Willmes DM, Kurzbach A, El-Agroudy NN, Bornstein SR, Schneider SA, Jordan J, Potschka H, Metallo CM, Köhling R, Birkenfeld AL, Löscher W.
Disruption of the sodium-dependent citrate transporter SLC13A5 in mice causes alterations in brain citrate levels and neuronal network excitability in the hippocampus.
Neurobiol Dis. 2020 Jul 16:105018. PMID:  32682952

Butenko K, Bahls C, Schröder M, Köhling R, van Rienen U.
OSS-DBS: Open-Source Simulation Platform for Deep Brain Stimulation with a comprehensive automated modeling.
PLoS Comput Biol. 2020 Jul 6;16(7):e1008023. PMID: 32628719

Möller S, Saul N, Cohen AA, Köhling R, Sender S, Murua Escobar H, Junghanss C, Cirulli F, Berry A, Antal P, Adler P, Vilo J, Boiani M, Jansen L, Struckmann S, Barrantes I, Hamed M, Luyten W, Fuellen G.
Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids.
Aging (Albany NY). 2020 Jul 7;12(13):12534-12581. PMID: 32634117

Kirschstein T, Sadkiewicz E, Hund-Göschel G, Becker J, Guli X, Müller S, Rohde M, Hübner D, Brehme H, Kolbaske S, Porath K, Sellmann T, Großmann A, Wittstock M, Syrbe S, Storch A, Köhling R.
Stereotactically injected Kv1.2 and CASPR2 antisera cause differential effects on CA1 synaptic and cellular excitability, but both enhance the vulnerability to pro-epileptic conditions.
Front Synaptic Neurosci. 2020 Mar 25;12:13. PMID: 32269520

Frerker B, Rohde M, Müller S, Bien C, Köhling R, Kirschstein T.
Distinct effects of stereotactically injected human cerebrospinal fluid containing glutamic acid decarboxylase antibodies into the hippocampus of rats on the development of spontaneous epileptic activity
Brain Sci. 2020 Feb 22;10(2). PMID: 32098388

Schulze F, Müller S, Guli X, Schumann L, Riffert T, Brehme H, Rohde M, Goerss G, Rackow S, Einsle A, Kirschstein T, Köhling R
CK2 inhibition prior to status epilepticus persistently enhances KCa2 function in CA1 which slows down disease progression
Front Cell Neurosci. 2020 Feb 26;14:33. PMID: 32174814

Baruah J, Vasudevan A, Köhling R.
Vascular-neuronal interplay determining brain development, network excitability and epileptogenesis.
Front Physiol. 2020 Jan 22;10:1583. PMID:32038280


Rohde M, Ziebart J, Kirschstein T, Sellmann T, Porath K, Kühl F, Dalenda B, Bahls C, Van Rienen U, Bader R, Köhling R.
Human osteoblast migration in DC electrical fields depends on store-operated Ca2+-release and is correlated to upregulation of stretch-activated TRPM7 channels.
Front Bioeng Biotechnol. 2019 Dec 12;7:422. PMID: 31921825

Ni H, Kirschstein T, Norwood BA, Hsieh CL.
Editorial: The Developmental Seizure-Induced Hippocampal Mossy Fiber Sprouting: Target for Epilepsy Therapies?
Front Neurol. 2019 Nov 13;10:1212. PMID: 31849807

Thiele F, Voelkner C, Krebs V, Müller P, Jung JJ, Rimmbach C, Steinhoff G, Noack T, David R, Lemcke H.
Nkx2.5 Based Ventricular Programming of Murine ESC-Derived Cardiomyocytes.
Cell Physiol Biochem. 2019;53(2):337-354. PMID: 31373783

Mayer J, Kirschstein T, Resch T, Porath K, Krause BJ, Köhling R, Lange F.
Perampanel attenuates epileptiform phenotype in C6 glioma.
Neurosci Lett. 2019 Nov 14:134629. PMID: 31734290

Köhling R.
Translational perspectives: Interneurones start seizures.
J Physiol. 2019 Oct 11. PMID: 31603536

Zschorlich V, Hillebrecht M, Tanjour T, Qi F, Behrendt F, Kirschstein T and Köhling R.
Repetitive peripheral magnetic nerve stimulation (rPMS) as adjuvant therapy reduces skeletal muscle reflex activity.
Front Neurol. 2019 Aug 27;10:930. PMID: 31507528

Fuellen G, Jansen L, Cohen AA, Luyten W, Gogol M, Simm A, Saul N, Cirulli F, Berry A, Antal P, Köhling R, Wouters B, Möller S.
Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways.
Aging Dis. 2019 Aug 1;10(4):883-900. PMID: 31440392

Patejdl R, Walter U, Rosener S, Sauer M, Reuter DA, Ehler J.
Muscular Ultrasound, Syndecan-1 and Procalcitonin Serum Levels to Assess Intensive Care Unit-Acquired Weakness.
Can J Neurol Sci. 2019 Mar;46(2):234-242. PMID: 30739614

Patejdl R, Gromann A, Bänsch D, Noack T.
Effects of ajmaline on contraction patterns of isolated rat gastric antrum and portal vein smooth muscle strips and on neurogenic relaxations of gastric fundus.
Pflugers Arch. 2019 Jul;471(7):995-1005. PMID: 31044280

Kersten M, Rabbe T, Blome R, Porath K, Sellmann T, Bien CG, Köhling R, Kirschstein T.
Novel Object Recognition in Rats With NMDAR Dysfunction in CA1 After Stereotactic Injection of Anti-NMDAR Encephalitis Cerebrospinal Fluid.
Front Neurol. 2019 Jun 5;10:586. PMID: 31231304

Hirose M, Schilf P, Zarse K, Busch H, Fuellen G, Jöhren O, Köhling R, König IR, Richer B, Rupp J, Schwaninger M, Seeger K, Sina C, Ristow M, Ibrahim SM.
Maternally Inherited Differences within Mitochondrial Complex I Control Murine Healthspan.
Genes (Basel). 2019 Jul 13;10(7). PMID: 31337008

Lange F, Weßlau K, Porath K, Hörnschemeyer J, Bergner C, Krause BJ, Mullins CS, Linnebacher M, Köhling R, Kirschstein T.
AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro.
PLoS One. 2019 Feb 4;14(2):e0211644. PMID: 30716120


Walter U, Fernández-Torre JL, Kirschstein T, Laureys S.
When is "brainstem death" brain death? The case for ancillary testing in primary infratentorial brain lesion.
Clin Neurophysiol. 2018 Nov;129(11):2451-2465. PMID:30209020

Gock M, Mullins C, Bergner C, Prall F, Ramer R, Goeder A, Krämer OH, Lange F, Krause BJ, Klar E, Linnebacher M.
Establishment, functional and genetic characterization of three novel patient-derived rectal cancer cell lines.
World J Gastroenterol 2018 November 21; 24(43): 4880-4892. PMID: 30487698

Reichart G, Mayer J, Zehm C, Kirschstein T, Tokay T, Lange F, Baltrusch S,Tiedge M, Fuellen G, Ibrahim S, Köhling R.
Mitochondrial complex IV mutation increases ROS production and reduces lifespan in aged mice.
Acta Physiol (Oxf).2018 Oct 30:e13214.
PMID: 30376218

Bajorat R, Porath K, Kuhn J, Goßla E, Goerss D, Sellmann T, Köhling R, Kirschstein T
Oral administration of the casein kinase 2 inhibitor TBB leads to persistent KCa2.2 channel up-regulation in the epileptic CA1 area and cortex, but lacks anti-seizure efficacy in the pilocarpine epilepsy model
Epilepsy Research 147, 42-50 (2018) PMID: 30219695

Blome R, Bach W, Guli X, Porath K, Sellmann T, Bien CG2, Köhling R, Kirschstein T.
Differentially Altered NMDAR Dependent and Independent Long-Term Potentiation in the CA3 Subfield in a Model of Anti-NMDAR Encephalitis.
Front Synaptic Neurosci. 2018 Jul 31;10:26. PMID: 30108497

Mader F, Müller S, Krause L, Springer A, Kernig K, Protzel C, Porath K, Rackow S, Wittstock T, Frank M, Hakenberg OW, Köhling R, Kirschstein T.
Hyperpolarization-Activated Cyclic Nucleotide-Gated Non-selective (HCN) Ion Channels Regulate Human and Murine Urinary Bladder Contractility.
Front Physiol. 2018 Jun 19;9:753. PMID: 29971015

Hirose M, Schilf P, Gupta Y, Zarse K, Künstner A, Fähnrich A, Busch H, Yin J, Wright MN, Ziegler A, Vallier M, Belheouane M, Baines JF, Tautz D, Johann K, Oelkrug R, Mittag J, Lehnert H, Othman A, Jöhren O, Schwaninger M, Prehn C, Adamski J, Shima K, Rupp J, Häsler R, Fuellen G, Köhling R, Ristow M, Ibrahim SM.
Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice.
Sci Rep. 2018 Apr 12;8(1):5872. PMID: 29651131

Müller S, Guli X, Hey J, Einsle A, Pfanz D, Sudmann V, Kirschstein T, Köhling R.
Acute epileptiform activity induced by gabazine involves proteasomal rather than lysosomal degradation of KCa2.2 channels.
Neurobiol Dis. 2018 Jan 9. pii: S0969-9961(18)30005-6. PMID: 29330041

Wallbaum P, Rohde S, Borufka L, Lange F, Hohn A, Bergner C, Schwarzenböck SM, Krause BJ, Jaster R.
Antifibrogenic effects of vitamin D derivatives on rat pancreatic stellate cells.
World J Gastroenterol. 2018 Jan 14;24(2):170-178. PMID: 29375203


Patejdl R, Zettl UK.
Spasticity in multiple sclerosis: Contribution of inflammation, autoimmune mediated neuronal damage and therapeutic interventions.
Autoimmun Rev. 2017 Sep;16(9):925-936. PMID: 28698092

Patejdl R, Kästner M, Kolbaske S, Wittstock M.
Clinical nutrition and gastrointestinal dysfunction in critically ill stroke patients.
Neurol Res. 2017 Nov;39(11):959-964. PMID: 28828964

Dammann⁠F, Kirschstein K, Guli X, Müller S, Porath K, Rohde M, Tokay⁠T, Köhling R.
Bidirectional shift of group III metabotropic glutamate receptor-mediated synaptic depression in the epileptic hippocampus.
Epilepsy Res. 2017 Dec 7. pii: S0920-1211(17)30405-9. PMID: 29224956

Neumann AM, Abele J, Kirschstein T, Engelmann R, Sellmann T, Köhling R, Müller-Hilke B.
Mycophenolate mofetil prevents the delayed T cell response after pilocarpine-induced status epilepticus in mice.
PLoS One. 2017 Nov 28;12(11):e0187330. PMID: 29182639

Additional files: Supporting Information

Hahn H, Kropp P, Kirschstein T, Rücker G, Müller-Hilke B.
Acute test anxiety in medical school does not predict academic performance, but correlates with a perceived imbalance between high efforts spent and low rewards received.
PLoS One. 2017 Feb 9;12(2):e0171220. PMID: 28182781

Rehberg M, Kirschstein T, Guli X, Müller S, Rohde M, Franz D, Tokay T, Köhling R.
Functional metaplasticity of hippocampal Schaffer collateral-CA1 synapses is reversed in chronically epileptic rats.
Neural Plast. 2017;2017:8087401. PMID: 29098091

Li S, Kumar T P, Joshee S, Kirschstein T, Subburaju S, Khalili JS, Kloepper J, Du C, Elkhal A, Szabó G, Jain RK, Köhling R, Vasudevan A.
Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior.
Cell Res. 2017 Oct 31. PMID: 29086765

Rohde S, Lindner T, Polei S, Stenzel J, Borufka L, Achilles S, Hartmann E, Lange F, Maletzki C, Linnebacher M, Glass Ä, Schwarzenböck SM, Kurth J, Hohn A, Vollmar B, Krause BJ, Jaster R.
Application of in vivo imaging techniques to monitor therapeutic efficiency of PLX4720 in an experimental model of microsatellite instable colorectal cancer.

. 2017 Jul 15. PMID: 28754868

Franz D, Olsen HL, Klink O, Gimsa J.
Automated and manual patch clamp data of human induced pluripotent stem cell-derived dopaminergic neurons.
Sci Data. 2017 Apr 25;4:170056. PMID: 28440808

Moeller M, Pink C, Endlich N, Endlich K, Grabe HJ, Völzke H, Dörr M, Nauck M, Lerch MM, Köhling R, Holtfreter B, Kocher T, Fuellen G.
Mortality is associated with inflammation, anemia, specific diseases and treatments, and molecular markers.
PLoS One. 2017 Apr 19;12(4):e0175909.  PMID: 28422991

Schindler N, Mayer J, Saenger S, Gimsa U, Walz C, Brenmoehl J, Ohde D, Wirthgen E, Tuchscherer A, Russo VC, Frank M, Kirschstein T, Metzger F, Hoeflich A.
Phenotype analysis of male transgenic mice overexpressing mutant IGFBP-2 lacking the Cardin–Weintraub sequence motif: Reduced expression of synaptic markers and myelin basic protein in the brain and a lower degree of anxiety-like behaviour.
Growth Horm IGF Res. 2016 Nov 16;33:1-8. PMID: 27919008


Patejdl R, Wittstock M, Zettl UK, Jost K, Grossmann A, Prudlo J
Neuromyelitis optica spectrum disorder coinciding with hematological immune disease: A case report.
Mult Scler Relat Disord. 2016 Sep;9:101-3. PMID: 27645353

Hirose M, Schilf P, Lange F, Mayer J, Reichart G, Maity P, Jöhren O, Schwaninger M, Scharffetter-Kochanek K, Sina C, Sadik CD, Köhling R, Miroux B, Ibrahim SM.
Uncoupling protein 2 protects mice from aging.
Mitochondrion. 2016 Jun 27. pii: S1567-7249(16)30078-2. PMID: 27364833

Kirschstein T, Wolters A, Lenz JH, Fröhlich S, Hakenberg O, Kundt G, Darmüntzel M, Hecker M, Altiner A, Müller-Hilke B
An algorithm for calculating exam quality as a basis for performance-based allocation of funds at medical schools.
GMS J Med Educ. 2016 May 17;33(3):Doc44. PMID: 27275509

Fröscher W, Kirschstein T, Rösche J.
Anticonvulsant therapy in brain-tumor related epilepsy.
J Epileptol. 2016; 24: 35-50.

Avchalumov Y, Kirschstein T, Köhling R.
Loss of GABAergic control of corticostriatal LTP following status epilepticus.
Transl Brain Rhythm. 2016;1:3-6.

Zettl UK, Rommer P, Hipp P, Patejdl R.
Evidence for the efficacy and effectiveness of THC-CBD oromucosal spray in symptom management of patients with spasticity due to multiple sclerosis.
Ther Adv Neurol Disord. 2016 Jan;9(1):9-30. PMID: 26788128

Zettl UK, Dudesek A, Rimmele F, Zettl H, Patejdl R
Autoimmune-Mediated Encephalomyelitis: a Heterogeneous Entity in Between Neurology and Psychiatry.
Fortschr Neurol Psychiatr. 2016 Oct;84(S 02):S84-S87.  PMID: 27806421

Patejdl R, Penner IK, Noack TK, Zettl UK.
Multiple sclerosis and fatigue: A review on the contribution of inflammation and immune-mediated neurodegeneration.
Autoimmun Rev. 2016 Mar;15(3):210-20. PMID: 26589194

Kretzschmar C, Roolf C, Timmer K, Sekora A, Knübel G, Escobar HM, Fuellen G, Ibrahim SM, Tiedge M, Baltrusch S, Jaster R, Köhling R, Junghanss C.
Polymorphisms of the murine mitochondrial ND4, CYTB and COX3 genes impact hematopoiesis during aging.
Oncotarget. 2016 Sep 10.  PMID: 27626489

Kretzschmar C, Roolf C, Timmer K, Sekora A, Knübel G, Escobar HM, Jaster R, Müller S, Fuellen G, Köhling R, Junghanss C.
Uncoupling protein 2 deficiency results in higher neutrophil counts and lower B-cell counts during aging in mice.
Exp Hematol. 2016 Nov;44(11):1085-1091.e2.  PMID: 27544660

Roolf C, Kretzschmar C, Timmer K, Sekora A, Knübel G, Escobar HM, Fuellen G, Ibrahim SM, Tiedge M, Baltrusch S, Müller S, Köhling R, Junghanss C.
Polymorphism in Murine mtATP8 Gene Correlates with Decreased Reactive Oxygen Species in Aging Hematopoietic Cells.
In Vivo. 2016 11-12;30(6):751-760. PMID: 27815458

Smita S, Lange F, Wolkenhauer O, Köhling R.
Deciphering hallmark processes of aging from interaction networks.
Biochim Biophys Acta. 2016 Jul 22. pii: S0304-4165(16)30264-1. PMID: 27456767

Köhling R, Wolfart J.
Potassium Channels in Epilepsy.
Cold Spring Harb Perspect Med. 2016 May 2;6(5). pii: a022871. PMID: 27141079

Avoli M, De Curtis M, Gnatkovsky V, Gotman J, Köhling R, Lévesque M, ManseauF, Shiri Z, Williams S.
Specific imbalance of excitatory/inhibitory signalingestablishes seizure onset pattern in temporal lobe epilepsy.
J Neurophysiol. 2016 Apr 13:jn.01128.2015. PMID: 27075542

Hackert JK, Müller L, Rohde M, Bien CG, Köhling R, Kirschstein T.
Anti-GAD65 Containing Cerebrospinal Fluid Does not Alter GABAergic Transmission.
Front Cell Neurosci. 2016 May 18;10:130. PMID: 27242441

Blank T, Detje Claudia N, Spieß A, Hagemeyer N, Brendecke Stefanie M, Wolfart J, Staszewski O, Zöller T, Papageorgiou I, Schneider J, Paricio-Montesinos R, Eisel Ulrich LM, Manahan-Vaughan D, Jansen S, Lienenklaus S, Lu B, Imai Y, Müller M, Goelz Susan E, Baker Darren P, Schwaninger M, Kann O, Heikenwalder M, Kalinke U, Prinz M
Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment.
Immunity 2016 44:901-912. PMID: 27096319

Bajorat R, Goerss D, Brenndörfer L, Schwabe L, Köhling R, Kirschstein T.
Interplay between interictal spikes and behavioral seizures in young, but notaged pilocarpine-treated epileptic rats.
Epilepsy Behav. 2016 Feb 26;57(PtA):90-94.  PMID: 26926072

Fuellen G, Schofield P, Flatt T, Schulz RJ, Boege F, Kraft K, Rimbach G, Ibrahim S, Tietz A, Schmidt C, Köhling R, Simm A.
Living Long and Well: Prospects for a Personalized Approach to the Medicine of Ageing.
Gerontology. 2015 Dec 17.  PMID: 26675034

Würdemann T, Kersten M, Tokay T, Guli X, Kober M, Rohde M, Porath K, Sellmann T, Bien CG, Köhling R, Kirschstein T.
Stereotactic injection of cerebrospinal fluid from anti-NMDA receptor encephalitis into rat dentate gyrus impairs NMDA receptor function.
Brain Res. 2016 Feb 15;1633:10-8.  PMID: 26721688

Köhling R, D’Antuono M, Benini R, de Guzman P, Avoli M.
Hypersynchronous ictal onset in the perirhinal cortex results from dynamic weakening in inhibition.
Neurobiol Dis. 2016 Mar;87:1-10. PMID: 26699817

Kirschstein T, Köhling R.
Animal models of tumour-associated epilepsy.
J Neurosci Methods. 2016 Feb 15;260:109-17. PMID: 26092434

Mader F, Krause L, Tokay T, Hakenberg OW, Köhling R, Kirschstein T.
Transient P2Y receptor-mediated relaxation in rat ileum involves phospholipase C activation, Ca2+ release from internal stores and SK channel activation.
Acta Pharmacol. Sin. (in press)

Xiati G, Tokay T, Kirschstein T, Köhling R.
Status epilepticus enhances depotentiation after fully established LTP in an NMDAR-dependent, but GluN2B-independent manner.
Neural Plast. 2016;2016:6592038. PMID: 26265316


Köhling R, and Wolfart J
Potassium channels in epilepsy.
2015 In: Additional Perspectives on Epilepsy: The Biology of a Spectrum Disorder (Noebels JL, Homes GL, eds). Cold Spring Harbor: Cold Spring Harbor Laboratory Press.

Paul K, Jaborg I, Patejdl R, Noack T.
Induction of a non-coherent relationship between  intracellular calcium and contractile force in arterial smooth muscle by treatment with (-) BAY K 8644.
Trace Elements and Electrolytes Vol. 32 –No. 4 (184 - 190)

Patejdl R, Leroux AC, Noack T.
Phenytoin inhibits contractions of rat gastrointestinal and portal vein smooth muscle by inhibiting calcium entry.
Neurogastroenterol Motil. 2015 Oct;27(10):1453-65. PMID: 26265316

Patejdl R, Penner IK, Noack TK, Zettl UK.
Fatigue in patients with multiple sclerosis--pathogenesis, clinical picture, diagnosis and treatment.
Fortschr Neurol Psychiatr. 2015 Apr;83(4):211-20. PMID: 25893494

Patejdl R, Penner IK, Noack TK, Zettl UK.
Multiple sclerosis and fatigue: A review on the contribution of inflammation and immune-mediated neurodegeneration.
Autoimmun Rev. 2015 Nov 14. (IF:7.933) PMID: 26589194

Patejdl R, Krohn S, Murua Escobar H, Zettl UK.
Fatal Acute Myeloid Leukemia With 11q23 MLL Gene Rearrangement Following Mitoxantrone Treatment in a Case of Childhood-onset Multiple Sclerosis.
J Pediatr Hematol Oncol.
2015 Jul;37(5):413-4. (IF:0.902) PMID: 25851557

Patejdl R, Noack, T.
Melastatin – Type Transient Receptor Potential Channel 7 (TRPM7) function in smooth muscle.

Trace Elements and Electrolytes.
Vol. 32 – No. 2/2015 (97-104)

Kirschstein T, Sahre T, Kernig K, Protzel C, Porath K, Köhling R, Hakenberg OW.
Inverse relationship of Rho kinase and myosin-light chain kinase expression in the aging human detrusor smooth muscle.
BMC Urol.
2015 Oct 15;15 (1):104. PMID: 25614054

Rösche J, Piek J, Hildebrandt G, Grossmann A, Kirschstein T, Benecke R
Perampanel in the Treatment of a Patient with Glioblastoma Multiforme without IDH1 Mutation and without MGMT Promotor Methylation.
Fortschr Neurol Psychiatr. 2015 May;83(5):286-9. PMID: 26018396

Holl N, Wuebbenhorst K, Behrens M, Zschorlich V.
The effect of age on coordination of stabilization during changing environmental dynamics.
Brain Res. 2015 Apr 16;1604:98-106. PMID: 25614054

Wolfart J,Laker D
Homeostasis or channelopathy? Acquired cell type-specific ion channel changes in temporal lobe epilepsy and their antiepileptic potential.
Front Physiol 2015; 6:168. PMID: 26018396

Krohn M, Bracke A, Avchalumov Y, Schumacher T, Hofrichter J, Paarmann K, Fröhlich C, Lange C, Brüning T, von Bohlen und Halbach O, Pahnke J.
Accumulation of murine beta-amyloid mimics early Alzheimer's disease.
2015 May 18. pii: awv137. PMID: 25991605

Schauer M, Kottek T, Schönherr M, Bhattacharya A, Simon JC, Ibrahim S, Hirose M, Möller M, Mörl M, Köhling R, Fuellen G, Schmitz U, Kunz M.
A mutation in the NADH-dehydrogenase subunit 2 negatively interferes with fibroblast ageing.
. 2015 Apr 20;6(11):8552-66. PMID: 25839158

Mayer J, Reichart G, Tokay T, Lange F, Baltrusch S, Junghanss C, Wolkenhauer O, Jaster R, Kunz M, Tiedge M, Ibrahim SM, Fuellen G, Köhling R.
Reduced Adolescent-Age Spatial Learning Ability Associated with Elevated Juvenile-Age Superoxide Levels in Complex I Mouse Mutants.
PLoS One. 2015 Apr 8;10(4):e0123863. PMID: 25853418

Weller J, Pose M, Protzel C, Mader F, Porath K, Köhling R, Hakenberg OW, Kirschstein T.
Age-related decrease of adenosine-mediated relaxation in rat detrusor is a result of A2B receptor downregulation.

Int J Urol
. 2015 Mar;22(3):322-9. PMID: 25728851

Chauhan A, Liebal UW, Vera J, Baltrusch S, Junghanß C, Tiedge M, Fuellen G, Wolkenhauer O, Köhling R.
Systems biology approaches in aging research.
Interdiscip Top Gerontol. 2015;40:155-76.PMID: 25341520

Yim MY, Hanuschkin A, Wolfart J.
Intrinsic rescaling of granule cells restores pattern separation ability of a dentate gyrus network model during epileptic hyperexcitability.
Hippocampus. 2015; 25:297-30. PMID: 25269417


Köhling R.
Prolonged seizures: what are the mechanisms that predispose or cease to be protective? A review of animal data.
Epileptic Disord. 2014 Oct;16 Suppl 1:23-36.PMID: 25323573

Brehme H, Kirschstein T, Schulz R, Köhling R.
In vivo treatment with the casein kinase 2 inhibitor 4,5,6,7- tetrabromotriazole augments the slow afterhyperpolarizing potential and prevents acute epileptiform activity.
Epilepsia. 2014 Jan;55(1):175-83. PMID: 24596964

Lange F, Franz B, Maletzki C, Linnebacher M, Hühns M, Jaster R.
Biological and molecular effects of small molecule kinase inhibitors on low-passage human colorectal cancer cell lines.
Biomed Res Int. 2014;2014:568693. PMID: 25309914

Müller S, Krüger B, Lange F, Bock CN, Nizze H, Glass A, Ibrahim SM, Jaster R.
The mtDNA nt7778 G/T Polymorphism Augments Formation of Lymphocytic Foci but Does Not Aggravate Cerulein-Induced Acute Pancreatitis in Mice.
PLoS One.
2014 Jul 10;9(7):e102266. PMID: 25010670

Müller S, Kaiser H, Krüger B, Fitzner B, Lange F, Bock CN, Nizze H, Ibrahim SM, Fuellen G, Wolkenhauer O, Jaster R.
Age-dependent effects of UCP2 deficiency on experimental acute pancreatitis in mice.
PLoS One. 2014 Apr 10;9(4):e94494.PMID: 24721982

Meier JC, Semtner M, Winkelmann A, Wolfart J.
Presynaptic mechanisms of neuronal plasticity and their role in epilepsy.
Front Cell Neurosci. 2014 Jun 17;8:164. PMID: 24987332

Behr C, D'Antuono M, Hamidi S, Herrington R, Lévesque M, Salami P, Shiri Z, Köhling R, Avoli M.
Limbic networks and epileptiform synchronization: the view from the experimental side.
Int Rev Neurobiol. 2014;114:63-87. PMID: 25078499

Moeller M, Hirose M, Mueller S, Roolf C, Baltrusch S, Ibrahim S, Junghanss C, Wolkenhauer O, Jaster R, Köhling R, Kunz M, Tiedge M, Schofield PN, Fuellen G.
Inbred mouse strains reveal biomarkers that are pro-longevity, antilongevity or role switching.
Aging Cell. 2014 Aug;13(4):729-38. PMID: 24862908

Avchalumov Y, Sander SE, Richter F, Porath K, Hamann M, Bode C, Kirschstein T, Köhling R, Richter A. 
Role of striatal NMDA receptor subunits in a model of paroxysmal dystonia. 
Exp Neurol. 2014 Aug 17;261C:677-684. PMID: 25139804

Fröscher W, Kirschstein T, Rösche J.
Anticonvulsant therapy for brain tumour-related epilepsy.
Fortschr Neurol Psychiatr. 2014 Dec;82(12):678-90. PMID: 25489755

Tokay T, Kirschstein T, Rohde M, Zschorlich V, Köhling R.
NMDA Receptor-Dependent Metaplasticity by High-Frequency Magnetic Stimulation.
Neural Plast. 2014;2014:684238. PMID: 25405036

Patejdl R
Magnesium in maintenance and regulation of smooth muscle function: A short review on basic mechanisms and clinical applications.
Trace Elements and Electrolytes Vol. 31- No. 4/2014 (190-199).

Ludwig M, Patejdl R, Steinhoff G, Noack T
Comparison of the electrophysiological properties of murine CD117(pos) stem cells with vascular smooth muscle cells (guinea-pig portal vein).
Trace Elements and Electrolytes Vol. 31 – No. 4/2014 (181-189).

Jaborg I, Patejdl R, Noack T
Light-induced induction of contractile dysfunction of smooth muscle during treatment with 5-aminolevulinic acid and Bay K 8644 - a possible alternative in tumor treatment.
Trace Elements and Electrolytes Vol. 31 - No. 3/2014 (89-95).


Walker MC, Köhling R.
The problems facing epilepsy therapy.
Neuropharmacology. 2013 Jun;69:1-2.PMID: 23435169

Müller L, Müller S, Sellmann T, Groeneweg L, Tokay T, Köhling R, Kirschstein T.
Effects of oxygen insufflation during pilocarpine-induced status epilepticus on mortality, tissue damage and seizures.
Epilepsy Res. 2014 Jan;108(1):90-7. PMID: 24315663

Patejdl R, Markmann S, Benecke R, Wittstock M.
Severe acute motor neuropathy after treatment with triple tyrosine kinase inhibitor BIBF 1120 (Nintedanib).
Clin Neurol Neurosurg. 2013 Sep;115(9):1851-2. PMID: 23414813

Kirschstein T, Protzel C, Porath K, Sellmann T, Köhling R, Hakenberg OW.
Age-dependent contribution of Rho kinase in carbachol-induced contraction of human detrusor smooth muscle in vitro.
Acta Pharmacol Sin. 2013 Oct 14. PMID: 24122009

Avchalumov Y, Volkmann CE, Rückborn K, Hamann M, Kirschstein T, Richter A, Köhling R.
Persistent changes of corticostriatal plasticity in dt(sz) mutant hamsters after age-dependent remission of dystonia.
Neuroscience. 2013 Oct 10;250:60-9. PMID: 23827309

Zschorlich VR, Köhling R.
How thoughts give rise to action - conscious motor intention increases the excitability of target-specific motor circuits.
PLoS One. 2013 Dec 26;8(12):e83845.PMID: 24386291

Mikkat S, Kirschstein T, Kreutzer M, Glocker MO.
Mass spectrometric peptide analysis of 2DE-separated mouse spinal cord and rat hippocampus proteins suggests an NGxG motif of importance for in vivo deamidation.
Electrophoresis. 2013 Jun;34(11):1610-8.PMID: 23512288

Klatte K, Kirschstein T, Otte D, Pothmann L, Müller L, Tokay T, Kober M, Uebachs M, Zimmer A, Beck H.
Impaired D-serine-mediated cotransmission mediates cognitive dysfunction in epilepsy.
J Neurosci. 2013 Aug 7;33(32):13066-80. PMID: 23926260

Kirchheim F, Tinnes S, Haas CA, Stegen M, Wolfart J.
Regulation of action potential delays via voltage-gated potassium Kv1.1 channels in dentate granule cells during hippocampal epilepsy.
Front Cell Neurosci. 2013 Dec 5;7:248.PMID: 24367293

Ludwig M, Skorska A, Tölk A, Hopp HH, Patejdl R, Li J, Steinhoff G, Noack T.
Characterization of ion currents of murine CD117(pos) stem cells in vitro and their modulation under AT2 R stimulation.
Acta Physiol (Oxf). 2013 Jul;208(3):274-87. PMID: 23648269


Avoli M, de Curtis M, Köhling R.
Does interictal synchronization influence ictogenesis?
Neuropharmacology. 2012 Jul 6.PMID: 22776544

Guli X, Tokay T, Rohde M, Bender RA, Köhling R, Kirschstein T.
ZD7288 Enhances Long-Term Depression at Early Postnatal Medial Perforant Path-Granule Cell Synapses.
Neural Plast. 2012;2012:237913.PMID: 22792490

Kirschstein T.
Synaptic plasticity and learning in animal models of tuberous sclerosis complex.
Neural Plast. 2012;2012:279834. PMID: 22848848

Patejdl R, Mix E, Zettl UK.
Keeping track of an expanding subject--recent trends in immunology and their clinical implications.
Curr Pharm Des. 2012;18(29):4441-2.PMID: 22873750

Patejdl R, Zettl UK.
Animal models in neurology: drawbacks and opportunities.
Curr Pharm Des. 2012;18(29):4443-52. PMID: 22612747

Müller L, Tokay T, Porath K, Köhling R, Kirschstein T.
Enhanced NMDA receptor-dependent LTP in the epileptic CA1 area via upregulation of NR2B.
Neurobiol Dis. 2013 Jan 8. PMID: 23313317

Zavaritskaya O, Zhuravleva N, Schleifenbaum J, Gloe T, Devermann L, Kluge R, Mladenov M, Frey M, Gagov H, Fésüs G, Gollasch M, Schubert R
Role of KCNQ Channels in Skeletal Muscle Arteries and Periadventitial Vascular Dysfunction.
Hypertension. 2013 Jan;61(1):151-9. PMID: 23184384

Avchalumov Y, Kirschstein T, Lukas J, Luo J, Wree A, Rolfs A, Köhling R.
Increased excitability and compromised long-term potentiation in the neocortex of NPC1(-/-) mice.
Brain Res. 2012 Mar 20;1444:20-6.PMID: 22325094


Rohde J, Kirschstein T, Wilkars W, Müller L, Tokay T, Porath K, Bender RA, Köhling R.
Upregulation of presynaptic mGluR2, but not mGluR3 in the epileptic medial perforant path.
Neuropharmacology. 2011 Dec 17. PMID: 22202905

Kernig K, Kirschstein T, Würdemann T, Rohde M, Köhling R.
The afterhyperpolarizing potential following a train of action potentials is suppressed in an acute epilepsy model in the Rat CA1 area.
Neuroscience. 2011 Nov 10. PMID: 22100272

Yan X, Lukas J, Witt M, Wree A, Hübner R, Frech M, Köhling R, Rolfs A, Luo J.
Decreased expression of myelin gene regulatory factor in Niemann-Pick type C 1 mouse.
Metab Brain Dis. 2011 Dec;26(4):299-306. PMID: 21938520

Kirschstein T, Mikkat S, Mikkat U, Bender R, Kreutzer M, Schulz R, Köhling R, Glocker MO.
The 27-kDa heat shock protein (HSP27) is a reliable hippocampal marker of full development of pilocarpine-induced status epilepticus.
Epilepsy Res. 2011 Sep 13.PMID: 21920704

Barmashenko G, Hefft S, Aertsen A, Kirschstein T, Köhling R.
Positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis are widespread after status epilepticus.
Epilepsia. 2011 Sep;52(9):1570-8.PMID: 21899534

Schulz R, Kirschstein T, Brehme H, Porath K, Mikkat U, Köhling R.
Network excitability in a model of chronic temporal lobe epilepsy critically depends on SK channel-mediated AHP currents.
Neurobiol Dis. 2012 Jan;45(1):337-47.PMID: 21889592

Bajorat R, Wilde M, Sellmann T, Kirschstein T, Köhling R.
Seizure frequency in pilocarpine-treated rats is independent of circadian rhythm.
Epilepsia. 2011 Sep;52(9):e118-22.PMID: 21801169

Köhling R, Staley K.
Network mechanisms for fast ripple activity in epileptic tissue.
Epilepsy Res. 2011 Dec;97(3):318-23. PMID: 21470826

Avchalumov Y, Kirschstein T, Köhling R.
Altered physiology and pharmacology in the corticostriatal system in a model of temporal lobe epilepsy.
Epilepsia. 2011 Jan;52(1):151-7. PMID: 21070218


Löscher W, Köhling R.
Functional, metabolic, and synaptic changes after seizures as potential targets for antiepileptic therapy.
Epilepsy Behav. 2010 Oct;19(2):105-13. PMID: 20705520

Weiergräber M, Stephani U, Köhling R.
Voltage-gated calcium channels in the etiopathogenesis and treatment of absence epilepsy.
Brain Res Rev. 2010 Mar;62(2):245-71. PMID: 20026356

Hildebrandt S, Schmidt A, Stoll A, Schmitt O, Köhling R, Wree A, Haas SJ, Pützer BM.
Targeting of neural stem cells in the hippocampus of adult rats by custom-made Ad vectors.
Brain Struct Funct. 2010 Aug;215(2):105-13. PMID: 20652310

Sommer N, Pak O, Schörner S, Derfuss T, Krug A, Gnaiger E, Ghofrani HA, Schermuly RT, Huckstorf C, Seeger W, Grimminger F, Weissmann N.
Mitochondrial cytochrome redox states and respiration in acute pulmonary oxygen sensing.
Eur Respir J. 2010 Jun 1. PMID: 20516051

Patejdl R, Noack T.
The Propagation of Excitation in Portal Vein Smooth Muscle - Evidence for Coupled "Hot Spots".
Trace Elements und Electrolytes, 27, 4, 202-208, 2010


Kirschstein T, Köhling R.
What is the source of the EEG?
Clin. EEG Neurosci. 2009 Jul; 40(3): 146-149. PMID: 19715175

Vasudevan, A., Ho, M., Weiergräber, M., Nischt, R., Schneider, T., Lie, A., Smyth, N., Köhling, R.
Basement membrane protein nidogen-1 shapes hippocampal synaptic plasticity and excitability.
Hippocampus 2009 Jun 15. PMID: 19530222

Tokay, T., Holl, N., Kirschstein, T., Zschorlich, V., Köhling, R.
High-frequency magnetic stimulation induces long-term potentiation in rat hippocampal slices.
Neurosci. Lett. 2009 Sep 18; 461(2): 150-154. PMID: 19539714

D’Antuono, M., Köhling, R., Ricalzone, S., Gotman, J. Biagini, G., Avoli, M.
Antiepileptic drugs abolish ictal but not interictal epileptiform discharges in vitro.
Epilepsia. 2010 Mar;51(3):423-31. PMID: 19694791

Kirschstein, T., Rehberg, M., Bajorat, R., Tokay, T., Porath, K., Köhling, R.
High K+-induced contraction requires depolarization-induced Ca2+-release from internal stores in rat gut smooth muscle.
Acta Pharmacol. Sin. 2009 Aug; 30(8): 1123-1131. PMID: 19578389

Kirschstein T, Dammann F, Klostermann J, Rehberg M, Tokay T, Schubert R, Köhling R.
Dopamine induces contraction in the proximal, but relaxation in the distal rat isolated small intestine. Neurosci. Lett. 2009 Nov 6; 465(1): 21-26. PMID: 19733212

Rohde M, Tokay T, Köhling R, Kirschstein T.
GABA(A) receptor inhibition does not affect mGluR-dependent LTD at hippocampal Schaffer collateral-CA1 synapses.
Neurosci. Lett. 2009 Dec 18; 467(1): 20-25. PMID: 19800390

Tokay T, Rohde M, Krabbe S, Rehberg M, Bender RA, Köhling R, Kirschstein T.
HCN1 channels constrain DHPG-induced LTD at hippocampal Schaffer collateral-CA1 synapses.
Learn Mem. 2009 Nov 25; 16(12):769-776. PMID: 19940037


Köhling, R.
Entstehungsmechanismen der Epilepsie - unkonventionelle Hypothesen
Zeitschrift für Epileptologie 2008; 4: 1-9.

Kirschstein, T., Bien, C.G., Bender, R.A.
Symposium "Kaliumkanäle bei Epilepsie"
Zeitschrift für Epileptologie 2008; 21: 153–155

Kirschstein, T.
Wie entsteht das EEG?
Neurophysiologisches Labor 2008; 30: 29–37

Strauss U, Zhou FW, Henning J, Battefeld A, Wree A, Köhling R, Haas SJ, Benecke R, Rolfs A, Gimsa U.
Increasing extracellular potassium results in subthalamic neuron activity resembling that seen in a 6-hydroxydopamine lesion.
J Neurophysiol. 2008 Jun;99(6):2902-15. PMID: 18385482

Diykov D, Barmashenko G, Hoffmann KP.
Development of chloride homeostasis in albino and pigmented rat visual cortex neurons.
Neuroreport 2008 Mar 25;19(5):595-8. PMID: 18388745

Martinka,P., Lai,E.Y., Fähling,M., Jankowski,V., Jankowski,J., Schubert,R., Gaestel,M., Persson,A.E., Persson,P.B., Patzak,A.:
Adenosine increases calcium sensitivity via receptor-independent activation of the p38/MK2 pathway in mesenteric arteries.
Acta Physiol.  2008 May;193(1):37-46. PMID: 18005245



Mladenov,M.I., Hristov,K.L., Dimitriova,D.Z., Schubert,R., Lubomirov,L.T., Gjorgoski,I.K., Duridanova,D.B., Gagov,H.S.:
Ghrelin signalling in guinea-pig femoral artery smooth muscle cells.
Acta Physiol (Oxf). 2008 Nov;194(3):195-206. PMID: 18577183

Schubert,R., Lidington,D., Bolz,S.S.
The emerging role of Ca2+ sensitivity regulation in promoting myogenic vasoconstriction.
Cardiovasc Res. 2008 Jan;77(1):8-18. PMID: 17764667


Meissner A., Noack, Th.
Proliferation of human lens epithelial cells (HLE-B3) is inhibited by blocking of voltage gated calcium channels
Pflügers Archiv - European Journal of Physiology 2008 Oct;457(1):47-59. Epub 2008 May 1.

Hourand, Chr., Hopp, H. H., Bentrup, M., and Noack, Th.
Graded hypoxia and blood vessel responses during potassium channel modulation in two vascular beds.


Schubert,R., Lidington,D., Bolz,S.S.
The emerging role of Ca2+ sensitivity regulation in promoting myogenic vasoconstriction.
Cardiovasc Res. 2008 Jan 1;77(1):8-18.

Ivanova,I.V., Schubert,R., Duridanova,D.B., Bolton,T.B., Lubomirov,L.T., Gagov,H.
Cocaine- and amphetamine-regulated transcript (CART) peptide as an in vivo regulator of cardiac function in Rana ridibunda frog.
Exp. Physiol. 92: 1037-1046 (2007)

Martinka,P., Lai,E.Y., Fähling,M., Jankowski,V., Jankowski,J., Schubert,R., Gaestel,M., Persson,A.E., Persson,P.B., Patzak,A.
Adenosine increases calcium sensitivity via receptor-independent activation of the p38/MK2 pathway in mesenteric arteries.
Acta Physiol (Oxf). 2007 Nov 14

Kirschstein T, Bauer M, Müller L, Rüschenschmidt C, Reitze M, Becker AJ, Schoch S, Beck H.
Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus.
J Neurosci. 2007 Jul 18;27(29):7696-704.

Bender RA, Kirschstein T, Kretz O, Brewster AL, Richichi C, Rüschenschmidt C, Shigemoto R, Beck H, Frotscher M, Baram TZ
Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation.
J Neurosci. 2007 Apr 25;27(17):4697-706.

Meissner A, Nebe B, Beck R, Guthoff R, Noack T
Importance of calcium and potassium currents in human lens epithelial cells (hLEC) and the effect of the calcium channel blocker mibefradil.

Köhling R, Ribak C:
Michael Forum Report
EPILEPSIA; 2007, S: 403-406.

Köhling R:
Pathophysiologie der Epilepsie

Köhling, R:

Pathomechanismen der Epilepsie
Z. f. Epileptol. 20: 1-14 (2007)


Lubomirov, L. T., Schubert, R., Gagov, H., Dwidanova, D., Pfitzer, G.:
Urocortin decreases via cAMP the phosphorylation of MYPT1 and increases the myosin phosphatase activity.
BIOFIZIKA 51 (5): 773-780 SEP-OCT 2006

Wolfer J, Bantel C, Köhling R, Speckmann EJ, Wassmann H, Greiner C.
Electrophysiology in ischemic neocortical brain slices: species differences vs. influences of anaesthesia and preparation.
Eur J Neurosci. 2006 Apr;23(7):1795-800.

Wallraff A, Köhling R, Heinemann U, Theis M, Willecke K, Steinhauser C.
The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus.
J Neurosci. 2006 May 17;26(20):5438-47.

Köhling R, Avoli M.
Methodological approaches to exploring epileptic disorders in the human brain in vitro.
J Neurosci Methods. 2006 Jul 15;155(1):1-19. Epub 2006 Jun 5. Review.

Köhling R, Nischt R, Vasudevan A, Ho M, Weiergraber M, Schneider T, Smyth N.
Nidogen and nidogen-associated basement membrane proteins and neuronal plasticity.
Neurodegener Dis. 2006;3(1-2):56-61. Review.

Köhling, R., Senner, V., Paulus, W., Speckmann, E.-J.
Epileptiform activity preferentially arises in paratumoural zone in glioma xenotransplants.
Neurobiol Dis. 2006 Apr;22(1):64-75.

von der Brelie C, Waltereit R, Zhang L, Beck H, Kirschstein T.
Impaired synaptic plasticity in a rat model of tuberous sclerosis.
Eur J Neurosci. 2006 Feb;23(3):686-92.

Rust,M.B., Faulhaber,J., Budack,M.K., Pfeffer,C., Maritzen,T., Didie,M., Beck,F.X., Boettger,T., Schubert,R., Ehmke,H., Jentsch,T.J., Hubner,C.A.:
Neurogenic Mechanisms Contribute to Hypertension in Mice With Disruption of the K-Cl Cotransporter KCC3.
Circ. Res. 98: 549-556 (2006)

Lubomirov,L.T., Reimann,K., Metzler,D., Hasse,V., Stehle,R., Ito,M., Hartshorne,D.J., Gagov,H., Pfitzer,G., Schubert,R.:
Urocortin-Induced Decrease in Ca2+ Sensitivity of Contraction in Mouse Tail Arteries Is Attributable to cAMP-Dependent Dephosphorylation of MYPT1 and Activation of Myosin Light Chain Phosphatase.
Circ. Res. 98: 1159-1167 (2006)

Koehler,R., Heyken,W.T., Heinau,P., Schubert,R., Si,H., Kacik,M., Busch,C., Grgic,I., Maier,T., Hoyer,J.:
Evidence for a Functional Role of Endothelial Transient Receptor Potential V4 in Shear Stress-Induced Vasodilatation.
Arterioscler. Thromb. Vasc. Biol. 26: 1495-1502 (2006)

Si,H., Heyken,W.T., Wolfle,S.E., Tysiac,M., Schubert,R., Grgic,I., Vilianovich,L., Giebing,G., Maier,T., Gross,V., Bader,M., de Wit,C., Hoyer,J., Kohler,R.:
Impaired Endothelium-Derived Hyperpolarizing Factor-Mediated Dilations and Increased Blood Pressure in Mice Deficient of the Intermediate-Conductance Ca2+-Activated K+ Channel.
Circ. Res. 99: 537-544 (2006)

Pfitzer,G., Lubomirov,L.T., Reimann,K., Gagov,H., Schubert,R.:
Regulation of the crossbridge cycle in vascular smooth muscle by cAMP signalling.
J. Muscle Res. Cell. Motil. 27: 445-454 (2006)

Sphingosine-1-phosphate in the circulatory system: Cause and therapeutic target for vascular dysfunction?
Cardiovasc. Res. 70: 9-11 (2006)

2005 und älter

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